PREOPERATIVE TRANSDERMAL SCOPOLAMINE DOES NOT REDUCE THE LEVEL OF NAUSEA AND FREQUENCY OF VOMITING AFTER LAPAROSCOPIC CHOLECYSTECTOMY

Objective: To determine the efficacy of scopolamine administered trans dermally before laparoscopic cholecystectomy as a means of reducing po stoperative nausea and vomiting. Design: A randomized, double-blind, p lacebo-controlled study. Setting: A tertiary-care, university-affiliat ed hospital. Patients: A volunteer sample of 125 men and women between 20 and 60 years of age scheduled to undergo elective laparoscopic cho lecystectomy. Expectant or nursing mothers were excluded, and 35 patie nts were excluded from the final analysis because of protocol violatio ns. Forty-three patients received scopolamine and 47 patients received a placebo. Intervention: A skin patch (scopolamine or placebo) was ap plied behind the right ear on the evening before operation and maintai ned for at least 24 hours postoperatively. Main Outcome Measures: The postoperative level of nausea assessed by the patient on a visual anal ogue scale, the frequency of vomiting and the frequency of antiemetic use. Results: There was no significant difference in the level of naus ea or in the frequency of emesis or use of antiemetics in the first 24 hours postoperatively between the control and study groups. Furthermo re, there was no difference in the overall frequency of side effects. However, visual blurring was experienced by six patients in the study group compared with one in the control group (p = 0.082). Conclusion: Scopolamine administered transdermally before laparoscopic cholecystec tomy does not. reduce the frequency or level of nausea and vomiting po stoperatively.