NOVEL ANTIASTHMATIC AGENTS WITH DUAL ACTIVITIES OF THROMBOXANE A(2) SYNTHETASE INHIBITION AND BRONCHODILATION .3. )]-2'-[2-(1-IMIDAZOLYL)ETHYL]-1(2H)-PHTHALAZINONES
M. Yamaguchi et al., NOVEL ANTIASTHMATIC AGENTS WITH DUAL ACTIVITIES OF THROMBOXANE A(2) SYNTHETASE INHIBITION AND BRONCHODILATION .3. )]-2'-[2-(1-IMIDAZOLYL)ETHYL]-1(2H)-PHTHALAZINONES, Chemical and Pharmaceutical Bulletin, 42(8), 1994, pp. 1601-1604
Synthesis and pharmacological evaluation of novel ethyl-2-thienyl)]-2-
[2-(1-imidazolyl)ethyl]-1(2H)- phthalazinones are described. The pheny
l moiety of the phthalazinone skeleton was found to play an important
role in both thromboxane A(2) synthetase-inhibitory and bronchodilator
y activities.