A MODIFIED MANNICH REACTION USING 1,3-DIOXOLANE

Authors
SUMITA K KOUMORI M OHNO S
Citation
K. Sumita et al., A MODIFIED MANNICH REACTION USING 1,3-DIOXOLANE, Chemical and Pharmaceutical Bulletin, 42(8), 1994, pp. 1676-1678
Citations number
15
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
42
Issue
8
Year of publication
1994
Pages
1676 - 1678
Database
ISI
SICI code
0009-2363(1994)42:8<1676:AMMRU1>2.0.ZU;2-#
Abstract
Mannich reaction of ketones using 1,3-dioxolane instead of formaldehyd e, paraformaldehyde, or 1,3,5-trioxane afforded the corresponding Mann ich bases in high yields. Under the same conditions the aminomethylati on of aromatics did not proceed but the intramolecular aminomethylatio n, like a Pictet-Spengler type reaction, proceeded smoothly.