ABSOLUTE STRUCTURE OF (-13-BETA-HYDROXYMAMANINE, A POSSIBLE METABOLITE OF (-)-BAPTIFOLINE())

Authors
KUBO H OHMIYA S HIGASHIYAMA K KAWAI K SAITO K MURAKOSHI I
Citation
H. Kubo et al., ABSOLUTE STRUCTURE OF (-13-BETA-HYDROXYMAMANINE, A POSSIBLE METABOLITE OF (-)-BAPTIFOLINE()), Chemical and Pharmaceutical Bulletin, 42(8), 1994, pp. 1706-1708
Citations number
6
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
42
Issue
8
Year of publication
1994
Pages
1706 - 1708
Database
ISI
SICI code
0009-2363(1994)42:8<1706:ASO(AP>2.0.ZU;2-V
Abstract
The absolute structure of (+)-13 beta-hydroxymamanine (1), isolated fr om an alkaloidal component of Maackia amurensis (Leguminosae), has bee n established as (7R, 9S, 11R, 13R) by the X-ray analysis of its hydro bromide. The absolute stereochemistry of 1 is the same as that of the structure corresponding to an oxidative product derived from (-)-bapti foline (7R, 9R, 11R, 13R) coexisting in the same plant. It was strongl y suggested that 1 might be an oxidative metabolite of (-)-baptifoline ,