EFFECTS OF TRANDOLAPRIL ON 24-H AMBULATORY BLOOD-PRESSURE IN PATIENTSWITH MILD-TO-MODERATE ESSENTIAL-HYPERTENSION

The effects of trandolapril on 24-h blood pressure in mild-to-moderate hypertensive patients of both sexes were investigated by conventional (clinic) and ambulatory recording in a double-blind study at two dosa ges, 1 mg (n = 14) and 2 mg (n = 13) once daily for 2 weeks. Both meth ods of measurement showed significant end-of-treatment decreases (p < 0.01 in all cases) in diastolic and systolic pressure in the 1- and 2- mg groups. Although intergroup differences were not significant, inspe ction of the mean changes from baseline in the eight 3-h periods const ituting the 24-h profile showed that reductions were consistently grea ter in the 2-mg than in the l-mg group, by 2 mm Mg diastolic blood pre ssure and 6 mm Mg systolic blood pressure. Values in the last segment of the placebo washout (46-48 h after the last active dose) showed tha t these reductions were well maintained, notably in the 2-mg group, wi th a minimal tendency to drift toward pretreatment levels. No effect w as observed on the normal circadian blood pressure rhythm. Both doses were well tolerated. In conclusion, trandolapril is an effective, well tolerated antihypertensive agent for once-daily dosing at either 1 or 2 mg.