THE EFFECT OF IMMUNIZATION OF PIGS WITH ASCARIS-SUUM CUTICLE COMPONENTS ON THE DEVELOPMENT OF RESISTANCE TO PARENTERAL MIGRATION DURING A CHALLENGE INFECTION
De. Hill et al., THE EFFECT OF IMMUNIZATION OF PIGS WITH ASCARIS-SUUM CUTICLE COMPONENTS ON THE DEVELOPMENT OF RESISTANCE TO PARENTERAL MIGRATION DURING A CHALLENGE INFECTION, Veterinary immunology and immunopathology, 42(2), 1994, pp. 161-169
The development of immunity to Ascaris suum was studied in pigs immuni
zed with isolated cuticle fragments from A. suum second and third stag
e larvae (L2/L3) and adult warms, and compared with other methods that
stimulate a strong protective response in pigs. A significant protect
ive response was seen in animals immunized with isolated cuticle fragm
ents from ii. suum L2/L3 and adults, but it was less than that seen in
animals inoculated with UV-irradiated eggs or naturally exposed to eg
gs on a dirt lot. Significant IgG responses to 2-mercaptoethanol (2ME)
-soluble cuticle components were seen in all groups, but the level of
the antibody response did not relate to protection. Group differences
in antibody and lymphocyte blastogenic responses to cuticle proteins i
ndicated quantitative and qualitative stage specific differences in 2M
E-soluble and insoluble cuticular proteins. Intestinal immunity was no
tably absent from cuticle immunized pigs because a marked liver white
spot response was observed following the challenge inoculation. Thus,
cuticle fragments from larval and adult A. suum are capable of inducin
g a protective response to larval migration; however, the development
of intestinal immunity is not a direct function of exposure to these a
ntigens.