EXCITOTOXICITY AND CHOLINERGIC CHEMICAL MARKERS DURING PROGRAMMED MOTOR-NEURON DEATH

Authors
RODRIGUEZITHURRALDE D VINCENT O
Citation
D. Rodriguezithurralde et O. Vincent, EXCITOTOXICITY AND CHOLINERGIC CHEMICAL MARKERS DURING PROGRAMMED MOTOR-NEURON DEATH, Journal of the neurological sciences, 124, 1994, pp. 52-53
Citations number
7
Categorie Soggetti
Neurosciences
Journal title
Journal of the neurological sciences → ACNP
ISSN journal
0022510X
Volume
124
Year of publication
1994
Supplement
S
Pages
52 - 53
Database
ISI
SICI code
0022-510X(1994)124:<52:EACCMD>2.0.ZU;2-M
Abstract
We measured cholinergic markers and acetylcholinesterase (AChE) molecu lar forms after glutamate receptor stimulation of superfused slices of mouse spinal cord at different developmental ages. AChE globular form s were secreted in a dose-dependent fashion. A period of selective sen sitivity to excitotoxic agents was detected by increased acetylcholine (ACh) release and AChE secretion (sAChE) at postnatal day 14. Strychn ine-resistant glycine stimulation potentiated glutamate-induced AChE r elease, suggesting N-methyl-D-aspartate (NMDA) receptor involvement.