MOTOR-NEURON DISEASE AND EXPOSURE TO CHEMICALS - ETIOLOGIC SUGGESTIONS FROM A CASE-CONTROL STUDY

A recent case-control study indicates that some males are genetically predisposed to develop motor neuron disease if they are exposed to che micals, particularly solvents. Markets for such a predisposition are h ereditary for a neurodegenerative disease and/or a thyroid disease. Th e reason for this susceptibility might be pharmacogenetic polymorphism , which causes deficient detoxification entailing oxidative stress and cell death.