THE EFFECT OF ETHYL-ALCOHOL ON THE SENSITIVITY OF UPPER AIRWAY REFLEXES

The effect of ethyl alcohol on upper airway reflex sensitivity (UARS) has not been previously investigated in humans. Using a technique that we have previously described, intermittent breaths of low concentrati ons of ammonia vapour were used to measure the effect of ethyl alcohol 0.55-0.66 g/kg on UARS in ten healthy male volunteers. The depression of upper airway reflexes that occurred following ingestion of ethyl a lcohol was maximum at 60 min and returned to baseline by 150 min. This dose of ethyl alcohol was insufficient to produce statistically signi ficant depression of UARS. The blood alcohol levels achieved showed a wide range with a mean of 78.9 mg/100 ml (SEM 10.3). Individual subjec ts who had blood alcohol levels in excess of 100 mg/100 ml displayed m uch greater depression of UARS. In conclusion, 0.55-0.66 g/kg ethyl al cohol given to healthy male volunteers does not produce significant de pression of UARS as measured using an ammonia stimulus technique.