MRI OF THE BRAIN IN MUSCLE-EYE-BRAIN (MEB) DISEASE

Muscle-eye-brain (MEB) disease belongs to the spectrum of rare congeni tal syndromes with migration disorders of the brain and muscular dystr ophy, along with the Walker-Warburg syndrome and Fukuyama congenital m uscular dystrophy. Their features overlap, and differential diagnosis presents some difficulties. We examined the brain of 10 patients with MEB using high-field MRI and found a uniform pattern consisting of a p achygyria-type cortical migration disorder, septal and corpus callosum defects and severe hypoplasia of the pons in 7 of them.