MERCAPTOACYL DIPEPTIDES AS DUAL INHIBITORS OF ANGIOTENSIN-CONVERTING ENZYME AND NEUTRAL ENDOPEPTIDASE - PRELIMINARY STRUCTURE-ACTIVITY STUDIES

Authors
DELANEY NG BARRISH JC NEUBECK R NATARAJAN S COHEN M ROVNYAK GC HUBER G MURUGESAN N GIROTRA R SIEBERMCMASTER E ROBL JA ASAAD MM CHEUNG HS BIRD JE WALDRON T PETRILLO EW
Citation
Ng. Delaney et al., MERCAPTOACYL DIPEPTIDES AS DUAL INHIBITORS OF ANGIOTENSIN-CONVERTING ENZYME AND NEUTRAL ENDOPEPTIDASE - PRELIMINARY STRUCTURE-ACTIVITY STUDIES, Bioorganic & medicinal chemistry letters, 4(15), 1994, pp. 1783-1788
Citations number
37
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
15
Year of publication
1994
Pages
1783 - 1788
Database
ISI
SICI code
0960-894X(1994)4:15<1783:MDADIO>2.0.ZU;2-7
Abstract
Mercaptoacyl dipeptides were prepared as dual-acting ACE/NEP inhibitor s. Inhibition of each enzyme may be explained by different binding mod els. Structure-activity studies determined that, in this series of com pounds, the mercaptopropanoyl dipeptide framework leads to increased a ffinity for NEP but diminished ACE activity in vivo.