DUAL METALLOPROTEASE INHIBITORS .2. EFFECT OF SUBSTITUTION AND STEREOCHEMISTRY ON BENZAZEPINONE BASED MERCAPTOACETYLS

Authors
ROBL JA SIMPKINS LM SULSKY R SIEBERMCMASTER E STEVENSON J KELLY YF SUN CQ MISRA RN RYONO DE ASAAD MM BIRD JE TRIPPODO NC KARANEWSKY DS
Citation
Ja. Robl et al., DUAL METALLOPROTEASE INHIBITORS .2. EFFECT OF SUBSTITUTION AND STEREOCHEMISTRY ON BENZAZEPINONE BASED MERCAPTOACETYLS, Bioorganic & medicinal chemistry letters, 4(15), 1994, pp. 1795-1800
Citations number
22
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
15
Year of publication
1994
Pages
1795 - 1800
Database
ISI
SICI code
0960-894X(1994)4:15<1795:DMI.EO>2.0.ZU;2-M
Abstract
A structure-activity study of dual-acting ACE/NEP inhibitor 1A.was ini tiated in order to ascertain what parameters effect in vitro activity versus ACE and NEP. Unlike NEP, ACE was found to be remarkably toleran t to a wide variety of permutations with respect to both the lactam nu cleus and the pharmacophore side chain.