SOLID-PHASE SYNTHESIS AND IMMUNOREACTIVITY OF PENTA-O-(N-ACETYL ALPHA-D-GALACTOSAMINYL)-MUC1 EICOSAPEPTIDE, A GLYCOSYLATED COUNTER PART OF THE HIGHLY IMMUNOGENIC TANDEM REPEAT SEQUENCE OF CARCINOMA-ASSOCIATED MUCIN

Authors
DUPRADEAU FY STROUD MR BOIVIN D LI LS HAKOMORI S SINGHAL AK TOYOKUNI T
Citation
Fy. Dupradeau et al., SOLID-PHASE SYNTHESIS AND IMMUNOREACTIVITY OF PENTA-O-(N-ACETYL ALPHA-D-GALACTOSAMINYL)-MUC1 EICOSAPEPTIDE, A GLYCOSYLATED COUNTER PART OF THE HIGHLY IMMUNOGENIC TANDEM REPEAT SEQUENCE OF CARCINOMA-ASSOCIATED MUCIN, Bioorganic & medicinal chemistry letters, 4(15), 1994, pp. 1813-1818
Citations number
36
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
15
Year of publication
1994
Pages
1813 - 1818
Database
ISI
SICI code
0960-894X(1994)4:15<1813:SSAIOP>2.0.ZU;2-Q
Abstract
Penta-O-glycosylated MUC1 peptide o-Ala-Pro-Gly-Ser-Thr*-Ala-Pro-Pro- Ala-His-Gly-OH (alpha-D-GalNAcp) (2) has been synthesized by a solid- phase method on Sasrin resin using Fmoc-glycoaminoacids 3 and 4 as bui lding blocks. The monoclonal antibodies SM3 and HMPV, specific to the MUC1 peptide 1, also react strongly with 2.