A. Datta et al., THE FIRST-SYNTHESIS OF A C-9 CARBONYL MODIFIED BACCATIN-III DERIVATIVE AND ITS CONVERSION TO NOVEL TAXOL(R) AND TAXOTERE(R) ANALOGS, Bioorganic & medicinal chemistry letters, 4(15), 1994, pp. 1831-1834
Treatment of 7,10-ditrocbaccatin III with potassium tert-butoxide resu
lted in the formation of a cyclic carbonate. Its taxol and taxotere an
alogues were found to possess good microtubule assembly properties but
exhibited poor in vitro cytotoxicity against B16 melanoma cells.