THE FIRST-SYNTHESIS OF A C-9 CARBONYL MODIFIED BACCATIN-III DERIVATIVE AND ITS CONVERSION TO NOVEL TAXOL(R) AND TAXOTERE(R) ANALOGS

Citation
A. Datta et al., THE FIRST-SYNTHESIS OF A C-9 CARBONYL MODIFIED BACCATIN-III DERIVATIVE AND ITS CONVERSION TO NOVEL TAXOL(R) AND TAXOTERE(R) ANALOGS, Bioorganic & medicinal chemistry letters, 4(15), 1994, pp. 1831-1834
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
ISSN journal
0960894X
Volume
4
Issue
15
Year of publication
1994
Pages
1831 - 1834
Database
ISI
SICI code
0960-894X(1994)4:15<1831:TFOACC>2.0.ZU;2-A
Abstract
Treatment of 7,10-ditrocbaccatin III with potassium tert-butoxide resu lted in the formation of a cyclic carbonate. Its taxol and taxotere an alogues were found to possess good microtubule assembly properties but exhibited poor in vitro cytotoxicity against B16 melanoma cells.