SYNTHESIS AND ANTITUMOR EVALUATION OF 2'-OXYCARBONYLPACLITAXELS (PACLITAXEL-2'-CARBONATES)

Authors
UEDA Y WONG H MATISKELLA JD MIKKILINENI AB FARINA V FAIRCHILD C ROSE WC MAMBER SW LONG BH KERNS EH CASAZZA AM VYAS DM
Citation
Y. Ueda et al., SYNTHESIS AND ANTITUMOR EVALUATION OF 2'-OXYCARBONYLPACLITAXELS (PACLITAXEL-2'-CARBONATES), Bioorganic & medicinal chemistry letters, 4(15), 1994, pp. 1861-1864
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
15
Year of publication
1994
Pages
1861 - 1864
Database
ISI
SICI code
0960-894X(1994)4:15<1861:SAAEO2>2.0.ZU;2-0
Abstract
A number of 2'-oxycarbonylpaclitaxels (paclitaxel-2'-carbonates) 3 hav e been prepared and evaluated for their cytotoxicity and in vivo antit umor activity. Most of these paclitaxel-2'-carbonates were found to ex hibit in vivo antitumor activity in the i.p. M109 murine tumor model s ystem, comparable to that of the parent drug.