ANALOGS OF THE MARINE NATURAL PRODUCT SCALARADIAL LACKING THE ALPHA,BETA-UNSATURATED ALDEHYDE - EFFECTS ON HUMAN SYNOVIAL-FLUID PHOSPHOLIPASE A(2) AND MACROPHAGE LIPID MEDIATOR PRODUCTION

Authors
GLASER KB SUNG ML LOCK YW BAUER J KUBRAK D KREFT A
Citation
Kb. Glaser et al., ANALOGS OF THE MARINE NATURAL PRODUCT SCALARADIAL LACKING THE ALPHA,BETA-UNSATURATED ALDEHYDE - EFFECTS ON HUMAN SYNOVIAL-FLUID PHOSPHOLIPASE A(2) AND MACROPHAGE LIPID MEDIATOR PRODUCTION, Bioorganic & medicinal chemistry letters, 4(15), 1994, pp. 1873-1878
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
15
Year of publication
1994
Pages
1873 - 1878
Database
ISI
SICI code
0960-894X(1994)4:15<1873:AOTMNP>2.0.ZU;2-8
Abstract
The role of the alpha,beta-unsaturated aldehyde in the inhibition of P LA(2) by scalaradial was investigated by reduction to the triol and ox idation to the diacid. The results demonstrate that the reactivity of the alpha,beta-unsaturated aldehyde of scalaradial is not absolutely e ssential to its ability to inhibit PLA(2) and lipid mediator productio n in the intact cell but adds significantly to its inhibitory potency.