SUPEROXIDE-DISMUTASE (CU ZN) AS AN OINTME NT FOR RADIOFIBROSIS THERAPY/

The aim of the paper consists to select criterias of the therapeutic e ffect of superoxide-dismutase (PEG-SOD) administrated as an ointment t wice a day for 3 months. An original scoring method including qualitat ive and quantitative data was set up in order to appreciate the import ance of the fibrosis and its variations when under local administratio n of PEG-SOD. Clinical and paraclinical controls were made as T0, T1 ( 6 weeks), T2 (3 months), T3 (6 months). After 6 months, results enable d us to show PEG-SOD in its galenic form was efficient on radiofibrosi s with a 41% score reduction compared to pretreatment score T0, thus a n improvement of nearly half of the potential theoretical recovery. Th e therapeutic efficiency was greater on the most recent fibrosis and t here was a chronological order to the different recovery stages. After 6 weeks of administration pains were reduced or stopped; then after 3 months of treatment fibrous texture broke up and softened. An effecti ve reduction of the surface as well as lightened of the pigmentation w ould not usually start until the 4th month after the start of treatmen t. PEG-SOD is thus an enzyme the therapeutic interest of which offers interesting prospects. The score which was set up enable a fair evalua tion of the intensity and the variations of the treated fibrosis. A pr ospective study is currently on going in order to research the biologi cal conditions in which the enzyme reacts.