The aim of the paper consists to select criterias of the therapeutic e
ffect of superoxide-dismutase (PEG-SOD) administrated as an ointment t
wice a day for 3 months. An original scoring method including qualitat
ive and quantitative data was set up in order to appreciate the import
ance of the fibrosis and its variations when under local administratio
n of PEG-SOD. Clinical and paraclinical controls were made as T0, T1 (
6 weeks), T2 (3 months), T3 (6 months). After 6 months, results enable
d us to show PEG-SOD in its galenic form was efficient on radiofibrosi
s with a 41% score reduction compared to pretreatment score T0, thus a
n improvement of nearly half of the potential theoretical recovery. Th
e therapeutic efficiency was greater on the most recent fibrosis and t
here was a chronological order to the different recovery stages. After
6 weeks of administration pains were reduced or stopped; then after 3
months of treatment fibrous texture broke up and softened. An effecti
ve reduction of the surface as well as lightened of the pigmentation w
ould not usually start until the 4th month after the start of treatmen
t. PEG-SOD is thus an enzyme the therapeutic interest of which offers
interesting prospects. The score which was set up enable a fair evalua
tion of the intensity and the variations of the treated fibrosis. A pr
ospective study is currently on going in order to research the biologi
cal conditions in which the enzyme reacts.