6-HALOPURINES IN PALLADIUM-CATALYZED COUPLING WITH ORGANOTIN AND ORGANOZINC REAGENTS

Authors
GUNDERSEN LL BAKKESTUEN AK AASEN AJ OVERAS H RISE F
Citation
Ll. Gundersen et al., 6-HALOPURINES IN PALLADIUM-CATALYZED COUPLING WITH ORGANOTIN AND ORGANOZINC REAGENTS, Tetrahedron, 50(32), 1994, pp. 9743-9756
Citations number
36
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
50
Issue
32
Year of publication
1994
Pages
9743 - 9756
Database
ISI
SICI code
0040-4020(1994)50:32<9743:6IPCWO>2.0.ZU;2-R
Abstract
N-9 and N-7 benzylated 6-halopurines readily participate in palladium catalyzed cross coupling reactions with organotin and organozinc deriv atives. In most instances the 6-chloropurines can be used. Organostann anes are excellent reagents for the introduction of alkenyl and aryl s ubstituents, but organozinc compounds are the reagents of choice for t he introduction of alkyl groups.