ADULT T-CELL LEUKEMIA WITH VARIOUS ABNORMALITIES IN ENDOCRINE AND METABOLIC SYSTEMS

Adult T-cell leukaemia (ATL) is a unique type of T-cell malignancy clo sely associated with human T-cell leukaemia virus-1 (HTLV-1). Despite frequent descriptions of hypercalcaemia, cases accompanied by diabetes insipidus or syndrome of inappropriate secretion of antidiuretic horm one (SIADH) in ATL patients have rarely been reported. We present an u nusual case of ATL with various abnormalities in his endocrine and met abolic systems involving anterior pituitary function, thyroid function , lipid metabolism and Ca metabolism. Some of these abnormalities were considered to arise from infiltration or leukaemic cells into systemi c organs after elimination of the above symptoms. Clinical and haemato logical data showing improvement following chemotherapy are also prese nted.