HYPERCALCEMIA IN B-CELL CHRONIC LYMPHOCYTIC-LEUKEMIA

Hypercalcaemia is common in some lymphoproliferative disorders such as myeloma or T-cell leukaemia-lymphoma, but is rarely described in B ce ll chronic lymphocytic leukaemia (BCLL). We report the case of a patie nt with BCLL, hypercalcaemia and osteolytic bone lesions. Parathyroid hromone-related protein (PTHrP) mRNA was identified by Northern blot a nalysis of liver, spleen and lymph node tumour samples. Serum levels o f tumour necrosis factor alpha (TNF alpha) were increased.