LIPID-PEROXIDATION PRODUCT IN BILE FROM PATIENTS WITH CARCINOMA OF THE GALLBLADDER - A PRELIMINARY-STUDY

Samples of gall bladder bile from patients with and without carcinoma of the gallbladder were examined for lipid peroxidation (free radical oxidation) products. 4-hydroxynonenal (HNE) was found in higher concen tration in the bile of patients with carcinoma of the gall bladder. Th ere was also a highly significant difference in the concentration of H NE among carcinoma of the gall bladder, cholelithiasis and control gro up of patients with miscellaneous abdominal disorders. This is the fir st study of lipid peroxidation in carcinoma of the gall bladder. (C) 1 994 Wiley-Liss, Inc.