SYNTHESIS OF ACYCLIC NUCLEOTIDE ANALOGS DERIVED FROM 6-HETARYLPURINESVIA CROSS-COUPLING REACTIONS OF -[2-(DIETHOXYPHOSPHONYLMETHOXY)ETHYL]-6-IODOPURINE WITH HETARYL ORGANOMETALLIC REAGENTS

Authors
HOCEK M MASOJIDKOVA M HOLY A
Citation
M. Hocek et al., SYNTHESIS OF ACYCLIC NUCLEOTIDE ANALOGS DERIVED FROM 6-HETARYLPURINESVIA CROSS-COUPLING REACTIONS OF -[2-(DIETHOXYPHOSPHONYLMETHOXY)ETHYL]-6-IODOPURINE WITH HETARYL ORGANOMETALLIC REAGENTS, Collection of Czechoslovak Chemical Communications, 62(1), 1997, pp. 136-146
Citations number
32
Categorie Soggetti
Chemistry
Journal title
Collection of Czechoslovak Chemical Communications → ACNP
ISSN journal
00100765
Volume
62
Issue
1
Year of publication
1997
Pages
136 - 146
Database
ISI
SICI code
0010-0765(1997)62:1<136:SOANAD>2.0.ZU;2-7
Abstract
The title acyclic nucleotide analogues derived fr om 6-hetarylpurines were prepared by Pd(0)-catalysed cross-coupling reactions of -[2-(diet hoxyphosphonylmethoxy)ethyl]-6-iodopurine (1) with hetarylorganometall ics: (pyridin-2-yl)-, (imidazol-2-yl)- and (pyrrol-2-yl)zinc chlorides or (imidazol-5-yl)- stannanes, followed by deprotection in fair to go od yields. The starting 6-iodopurine derivative 1 was prepared by iodo deamination of the adenine derivative.