SYNTHESIS OF SOME DIBENZODIAZEPIONE DERIVATIVES AS POTENT AND M2-SELECTIVE ANTIMUSCARINIC COMPOUNDS

Authors
COHEN VI JIN BY GITLER MS DELACRUZ RA RZESZOTARSKI WJ ZEEBERG BR BAUMGOLD J REBA RC
Citation
Vi. Cohen et al., SYNTHESIS OF SOME DIBENZODIAZEPIONE DERIVATIVES AS POTENT AND M2-SELECTIVE ANTIMUSCARINIC COMPOUNDS, Journal of heterocyclic chemistry, 31(4), 1994, pp. 787-791
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of heterocyclic chemistry → ACNP
ISSN journal
0022152X
Volume
31
Issue
4
Year of publication
1994
Pages
787 - 791
Database
ISI
SICI code
0022-152X(1994)31:4<787:SOSDDA>2.0.ZU;2-W
Abstract
Two series of -[[4-[4-(dialkylamino)butyl]-1-cyclohexyl]acetyl], and 1 0,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-11-ones were synthesized as potential m2-selective ligands 1,2. Their affinity and selectivity for the muscarinic cholinergic receptor m-AChR subtypes were determined. Replacing a nitrogen with CH in the piperidine ring of 0,11-dihydro-5H -dibenzo-[b,e][1,4]diazepin-11-ones 3 significantly altered the affini ty and selectivity to the muscarinic receptor subtypes.