Sp. Langdon et al., THE REGULATION OF GROWTH AND PROTEIN EXPRESSION BY ESTROGEN IN-VITRO - A STUDY OF 8 HUMAN OVARIAN-CARCINOMA CELL-LINES, Journal of steroid biochemistry and molecular biology, 50(3-4), 1994, pp. 131-135
The effects of 17 beta-estradiol (E(2)) on the growth and the levels o
f estrogen receptor (ER), progesterone receptor (PR) and pS2 protein w
ere examined in a range of 8 ovarian carcinoma cell lines. E(2) stimul
ated growth of the 3 cell lines with an ER content of 80-220 fmol/mg p
rotein but not the 5 cell lines with ER concentrations less than 20 fm
ol/mg protein, After exposure to E(2), ER concentration in 2 of the 3
responsive cell lines was decreased relative to untreated cells and in
2 lines, progesterone receptors were increased. No change in steroid
receptor levels-was observed in cell lines with low or negligible leve
ls of receptors. The pS2 protein was not induced by E(2) in the 5 ovar
ian carcinoma cell lines examined. These results indicate that E(2) ca
n stimulate the growth of some ER-positive ovarian carcinoma cells and
that these effects may be associated with changes in the cellular lev
els of steroid hormone receptors.