CHEMICAL STRESS-RELAXATION OF POLYGLYCOLIC ACID SUTURE

Chemical stress relaxation methods are employed to study chemical and mechanical factors influencing the degradation of uncoated polyglycoli c acid (PG) sutures. Specially constructed instrumentation is used to study the kinetics of the load bearing capability of PG (Dexon(TM)) 3- 0 sutures in hydrolytic solution. The effects of pH, temperature, stra in rate, and initial load on the rate of chemical stress relaxation ar e presented. Data show how mechanical factors such as the rate of load ing (related to the speed of knot tying), as well as the final tension , are related to the rate of structural degradation. Maximum stability is observed at approximately 40 degrees C, with slower degradation bo th above and below this point. Results show that the slower and tighte r the suture is pulled, the greater its ability to sustain tensile loa ds during hydrolysis. (C) 1994 John Wiley & Sons, Inc.