F. Fakan et M. Michal, NODULAR TRANSFORMATION OF SPLENIC RED PULP DUE TO CARCINOMATOUS INFILTRATION - A DIAGNOSTIC PITFALL, Histopathology, 25(2), 1994, pp. 175-178
Autopsy of three women dying of disseminated carcinoma of stomach, col
on, and breast, respectively, revealed a grossly unremarkable spleen.
Microscopic examination demonstrated a nodular transformation of the r
ed pulp, simulating a follicular lymphoma. Immunostaining revealed dis
sociated carcinomatous cells between the nodules, and this was thought
to be the cause of the nodular transformation.