Parotid gland biopsy was performed in 32 female patients affected by s
uspected Sjogren's syndrome. In all cases histologic findings were in
agreement with this diagnosis and in two subjects led us to detect the
malignant transformation into lymphoma. None of the patients develope
d relevant complications. Our study indicates that parotid gland biops
y in Sjogren's syndrome is a safe procedure and may be useful in perfo
rming diagnosis.