CHARGE-TRANSFER CHROMATOGRAPHIC STUDY OF THE INTERACTION OF ANTICANCER DRUGS WITH ACETYL-BETA-CYCLODEXTRIN

The interaction between 23 anticancer drugs and acetyl-beta-cyclodextr in (acetyl-beta-CD) was studied by reversed-phase charge-transfer thin -layer chromatography and the relative strength of interaction was cal culated. Acetyl-beta-CD formed inclusion complexes with 16 compounds, the complex always being more hydrophilic than the uncomplexed drug. T he inclusion forming capacity of drugs differed considerably according to their chemical structure. The significant linear correlation betwe en the hydrophobicity and specific hydrophobic surface area of antican cer drugs indicated that they can be considered as a homologous series of compounds, however, their chemical structures are highly different .