Physical and chemical injuries account for the largest number of sudde
n, unexpected cardiac deaths in persons between the ages of 1 and 44 y
ears. Blunt-force injuries, lacerations, avulsions, and contusions of
the heart and great vessels sustained during motor vehicle crashes con
stitute the most prevalent type of lethal physical trauma to the cardi
ovascular system. The second most prevalent type of trauma is from pen
etrating and perforating wounds inflicted by firearms. The mechanisms
of these injuries are discussed, with emphasis placed on those factors
contributing to lethality. The three most prevalent chemicals associa
ted with sudden cardiac death-ethyl alcohol, cocaine, and tricylic ant
idepressants-are briefly mentioned.