SITE-DIRECTED MUTAGENESIS OF PENICILLIN-BINDING PROTEIN-3 OF ESCHERICHIA-COLI - ROLE OF VAL-545

Authors
AYALA J GOFFIN C NGUYENDISTECHE M GHUYSEN JM
Citation
J. Ayala et al., SITE-DIRECTED MUTAGENESIS OF PENICILLIN-BINDING PROTEIN-3 OF ESCHERICHIA-COLI - ROLE OF VAL-545, FEMS microbiology letters, 121(2), 1994, pp. 251-256
Citations number
14
Categorie Soggetti
Microbiology
Journal title
FEMS microbiology letters → ACNP
ISSN journal
03781097
Volume
121
Issue
2
Year of publication
1994
Pages
251 - 256
Database
ISI
SICI code
0378-1097(1994)121:2<251:SMOPPO>2.0.ZU;2-D
Abstract
Val545 of the Escherichia coli penicillin-binding protein 3 is essenti al to the acyl transfer mechanism through which the active-site serine 307 is acylated by benzylpenicillin and cephalexin and to the mechani sm through which the protein allows rapidly growing cells to divide.