INDAPAMIDE OR HYDROCHLOROTHIAZIDE IN HYPERTENSIVE PATIENTS RESISTANT TO TREATMENT WITH AN ANGIOTENSIN-CONVERTING ENZYME-INHIBITOR

This randomized, double-blind, parallel-group study evaluated combinat ion therapy in 31 patients with mild-to-moderate hypertension whose bl ood pressure levels were not controlled by enalapril, 20 mg/d, monothe rapy. Patients were divided into two groups. Group 1 (n = 15) continue d enalapril and received indapamide, 2.5 mg/d; group 2 (n = 16) contin ued enalapril and received hydrochlorothiazide 25 mg/d. After 12 weeks of treatment, both combinations were equally effective in lowering bl ood pressure; normalized blood pressure levels were seen in 11 patient s in each group. Decreases in serum potassium levels and increases in uric acid levels were significant in both groups. Triglyceride blood l evels increased significantly more in the hydrochlorothiazide group th an in the indapamide group; other metabolic parameters were unaffected by both treatments.