Purpose: The authors report their experience with the surgical removal
of subfoveal choroidal neovascularization. Correlations between preop
erative characteristics and final postoperative visual acuity are expl
ored. Methods: A retrospective study of 159 consecutive patients was p
erformed between February 1990 and August 1993. Follow-up of 2 or more
months was available for 147 eyes: presumed ocular histoplasmosis syn
drome, 67 eyes; age-related macular degeneration, 41 eyes; myopia, 10
eyes; multifocal choroiditis, 9 eyes; idiopathic, 8 eyes; angioid stre
aks, 4 eyes; and miscellaneous, 8 eyes. Results: Sixty-seven eyes had
presumed ocular histoplasmosis syndrome: mean follow-up was 10.5 month
s. Visual acuity was stable or improved in 56 (83%) eyes and 20/40 or
greater in 21 (31%) eyes. Mean interval to best visual acuity was 3 mo
nths. A recurrence rate of 37% had no significant effect on final visu
al outcome (P = 0.952). Forty-one eyes had age-related macular degener
ation: mean follow-up was 15 months. Visual acuity was improved in onl
y five (12%) eyes and was 20/40 or greater in only two (5%) eyes. The
interval to best visual acuity was 5 months. A recurrence rate of 27%
had no significant effect on final visual outcome (P = 0.31). The visu
al results and recurrence rates for eyes with less common disorders ar
e presented. Conclusion: The surgical excision of subfoveal choroidal
neovascularization may stabilize or improve visual acuity in selected
cases. Patients with focal disorders of the retinal pigment epithelium
-Bruch's membrane complex appear to have a better surgical outcome tha
n those with diffuse disease.