EFFECTS OF 8-METHOXYPSORALEN PLUS UVA RADIATION (PUVA) ON GLUTATHIONE-PEROXIDASE AND LIPID PEROXIDE PLASMA-LEVELS IN PSORIASIC PATIENTS

Authors
BEANI JC RICHARD MJ BERTHOD F ARNAUD J AMBLARD P FAVIER A
Citation
Jc. Beani et al., EFFECTS OF 8-METHOXYPSORALEN PLUS UVA RADIATION (PUVA) ON GLUTATHIONE-PEROXIDASE AND LIPID PEROXIDE PLASMA-LEVELS IN PSORIASIC PATIENTS, EJD. European journal of dermatology, 4(6), 1994, pp. 480-484
Citations number
29
Categorie Soggetti
Dermatology & Venereal Diseases
Journal title
EJD. European journal of dermatology → ACNP
ISSN journal
11671122
Volume
4
Issue
6
Year of publication
1994
Pages
480 - 484
Database
ISI
SICI code
1167-1122(1994)4:6<480:EO8PUR>2.0.ZU;2-Z
Abstract
Since he role of free radicals in skin photocarcinogenesis is now susp ected, we undertook the present work in order to verify the action of PUVA on lipid peroxidation and on the systems repairing oxidizing stre ss in vivo. Plasma vitamins (tocopherol and retinol), plasma trace ele ments (Cu, Zn, Se), metalloenzymes (selenium dependent GPX, SeGPX) and lipid peroxidation markers (malondialdehyde (MDA), and organic hydrop eroxide) were measured before (DO) and during PUVA treatment (Day 15 a nd Day 45). A significant increase of MDA and decrease of Se GPX was o bserved during PUVA but no significant change for other parameters. Th e significance of these modifications is discussed.