INTRATUBULAR GERM-CELL NEOPLASIA (ITGCN) WITH P53 AND PCNA EXPRESSIONAND ADJACENT MATURE TERATOMA IN AN INFANT TESTIS - AN IMMUNOHISTOCHEMICAL AND MORPHOLOGIC STUDY WITH A REVIEW OF THE LITERATURE

Intratubular germ cell neoplasia (ITGCN) and mature teratoma of the te stis are uncommon findings in children. We report a case of a 3-year-o ld boy with both ITGCN and mature teratoma-a unique finding in our exp erience. Immunohistochemical markers, including placental alkaline pho sphatase (PLAP), 43-9F, p53, and proliferating cell nuclear antigen (P CNA), as well as the periodic acid-Schiff (PAS) stain, were applied to the ITGCN. PLAP and 43-9F were not detected, whereas p53 and PCNA nuc lear expression was detected in similar to 5% of atypical germ cells. Abundant clumped intracytoplasmic glycogen deposits were identified wi thin atypical germ cells. Our findings indicate that both PCNA and p53 , in addition to a PAS stain, may be useful markers in detecting malig nant intratubular germ cells.