K. Suzuki et al., USEFULNESS OF DIALYSATE FIBRIN DEGRADATION PRODUCTS AND LACTIC-DEHYDROGENASE ISOENZYME PATTERNS IN ASSESSING THE CLINICAL COURSE OF PERITONITIS, Peritoneal dialysis international, 14(3), 1994, pp. 231-235
Objective: To establish the usefulness of fibrin degradation products
(FDP) and lactic dehydrogenase isoenzyme patterns (LDH isoenzyme) in a
ssessing the clinical course of peritonitis. Design: A retrospective s
tudy of patients with peritonitis who were divided into three groups a
ccording to their clinical course. Setting: Single dialysis unit of a
general hospital. Interventions: Patients were treated by intraperiton
eal and oral antibiotics. Patients:Twenty-six patients with 34 episode
s of peritonitis were studied. Group 1 consisted of 21 patients with 2
6 recoveries from peritonitis; Group 2 consisted of 5 patients with 5
relapsing episodes of peritonitis, and Group 3 consisted of 3 patients
with 3 persistent episodes of peritonitis. Main Outcome Measures: Con
centrations of WBCs, FDP, LDH isoenzyme and microbiological culture of
the dialysate were determined. Results: In most of Group 1, WBCs, FDP
, and LDH isoenzyme returned to normal within 2 weeks. In 4 patients o
f Group 1, who had complications (diverticulitis, cholecystitis, cysti
tis, and tunnel infection), WBCs, FDP, and LDH isoenzyme returned to n
ormal gradually within 3 weeks. In Group 2, WBCs returned to normal, b
ut FDP remained relatively high and LDH isoenzyme did not normalize. I
n Group 3, WBCs, FDP and LDH isoenzyme did not normalize. Conclusions:
Failure of normalization of FDP and LDH isoenzyme suggests an incompl
ete recovery from peritonitis. FDP and LDH isoenzyme are useful in ass
essing the course of peritonitis.