Hj. Normile et al., ACTIVATION OF ADENOSINE A(1) RECEPTORS IN THE NUCLEUS-ACCUMBENS IMPAIRS INHIBITORY AVOIDANCE MEMORY, Behavioral and neural biology, 62(2), 1994, pp. 163-166
Potent and highly selective adenosine A(1) and A(2) receptor agonists
were bilaterally injected into the nucleus accumbens of mice 10 min pr
ior to inhibitory avoidance training. Retention of the inhibitory avoi
dance response was assessed 24 h after training. Intra-ACB activation
of A(1) receptors, but not A(2a) receptor activation, significantly im
paired the performance of mice during the subsequent retention test. F
urthermore, the retention deficit produced by activation of A(1) recep
tors was significantly attenuated by pretreating mice with a highly se
lective A(1) receptor antagonist. These findings suggest that endogeno
us adenosine may modulate information processing in the ventral striat
um via adenosine A(1) receptors. (C) 1994 Academic Press, Inc.