INFLUENCE OF BIPERIDEN AND BORNAPRINE ON SLEEP IN HEALTHY-SUBJECTS

Citation
F. Hohagen et al., INFLUENCE OF BIPERIDEN AND BORNAPRINE ON SLEEP IN HEALTHY-SUBJECTS, Neuropsychopharmacology, 11(1), 1994, pp. 29-32
Citations number
22
Categorie Soggetti
Neurosciences,Psychiatry,"Pharmacology & Pharmacy
Journal title
Neuropsychopharmacology
ISSN journal
0893133X → ACNP
Volume
11
Issue
1
Year of publication
1994
Pages
29 - 32
Database
ISI
SICI code
0893-133X(1994)11:1<29:IOBABO>2.0.ZU;2-4
Abstract
Biperiden, 4 mg, an anticholinergic drug that is relatively selective for the M1 receptor subtype, and bornaprine, mg, a nonselective M1 and M2 antagonist, were administered orally in a randomized, double-blind design to twelve healthy volunteers to investigate the effect on poly somnographically recorded sleep. Both drugs suppressed rapid eye movem ent (REM) sleep as reflected by an increase of REM latency and a decre ase in the percentage of REM sleep period time with the effects of bip eriden being more pronounced. No significant effect on slow wave sleep was observed. The results of this study support the hypothesis that b oth the M1 and the M2 receptor subtype are involved in the regulation of REM sleep in humans.