MODULATION OF THE OXIDATIVE BURST IN MOUSE MACROPHAGES AND HUMAN NEUTROPHILS BY SUPERLOW CONCENTRATIONS OF GM1 GANGLIOSIDE

Authors
AVROVA NF IVANOVA VP TYURIN VA GAMALEI IA KLYUBIN IV SHCHEPETKIN IA BORUNOV EV TYURINA YY
Citation
Nf. Avrova et al., MODULATION OF THE OXIDATIVE BURST IN MOUSE MACROPHAGES AND HUMAN NEUTROPHILS BY SUPERLOW CONCENTRATIONS OF GM1 GANGLIOSIDE, Bulletin of experimental biology and medicine, 117(1), 1994, pp. 45-47
Citations number
11
Categorie Soggetti
Medicine, Research & Experimental
Journal title
Bulletin of experimental biology and medicine → ACNP
ISSN journal
00074888
Volume
117
Issue
1
Year of publication
1994
Pages
45 - 47
Database
ISI
SICI code
0007-4888(1994)117:1<45:MOTOBI>2.0.ZU;2-4
Abstract
It is shown that ganglioside GM1 in picomolar concentrations stimulate s the phorbol-12-myristate-13-acetate (PMA)-induced generation of acti ve forms of oxygen by neutrophils and peritoneal macrophages. GM1 (10( -11) M) is found to enhance the luminol-dependent chemiluminescence in duced by 10(-8) M PMA in mouse macrophages in comparison with the effe ct of PMA alone.