INTERACTION BETWEEN MULTIPLY MODIFIED (DESIALYLATED) LOW-DENSITY LIPOPROTEINS ISOLATED FROM BLOOD OF ATHEROSCLEROTIC PATIENTS AND CELL RECEPTORS

Authors
TERTOV VV SOBENIN IA NAZAROVA VL GILDIEVA BS VIA DP OREKHOV AP
Citation
Vv. Tertov et al., INTERACTION BETWEEN MULTIPLY MODIFIED (DESIALYLATED) LOW-DENSITY LIPOPROTEINS ISOLATED FROM BLOOD OF ATHEROSCLEROTIC PATIENTS AND CELL RECEPTORS, Bulletin of experimental biology and medicine, 117(1), 1994, pp. 55-57
Citations number
12
Categorie Soggetti
Medicine, Research & Experimental
Journal title
Bulletin of experimental biology and medicine → ACNP
ISSN journal
00074888
Volume
117
Issue
1
Year of publication
1994
Pages
55 - 57
Database
ISI
SICI code
0007-4888(1994)117:1<55:IBMM(L>2.0.ZU;2-N
Abstract
It is shown that binding of native LDL to fibroblasts expressing the B ,E-receptors is twice as high as that of desialylated LDL. An excess o f acetylated LDL inhibits binding, uptake, and degradation of I-125-de sialylated LDL by macrophages, while an excess of desialylated LDL inh ibits binding, uptake, and degradation of acetylated LDL. Desialylated LDL may interact with both B,E and scavenger receptors.