INHIBITION OF IL-2-DEPENDENT PROLIFERATION OF HUMAN-LYMPHOCYTES AND OF THE EXPRESSION OF INTERLEUKIN-2 RECEPTORS BY SYNTHETIC PEPTIDE-FRAGMENTS OF ALPHA-2 INTERFERON

Authors
DANILKOVICH AV FREZE KV TARGONI OS KARULIN AY SHEVALE AF GUSEV MV SUKHIKH GT
Citation
Av. Danilkovich et al., INHIBITION OF IL-2-DEPENDENT PROLIFERATION OF HUMAN-LYMPHOCYTES AND OF THE EXPRESSION OF INTERLEUKIN-2 RECEPTORS BY SYNTHETIC PEPTIDE-FRAGMENTS OF ALPHA-2 INTERFERON, Bulletin of experimental biology and medicine, 117(1), 1994, pp. 68-70
Citations number
4
Categorie Soggetti
Medicine, Research & Experimental
Journal title
Bulletin of experimental biology and medicine → ACNP
ISSN journal
00074888
Volume
117
Issue
1
Year of publication
1994
Pages
68 - 70
Database
ISI
SICI code
0007-4888(1994)117:1<68:IOIPOH>2.0.ZU;2-Y
Abstract
It is shown that biologically active peptides inhibit the concanavalin A-induced generation of cells which may proliferate in response to ex ogenous recombinant interleukin-2. Determination of the number of CD25 -containing cells showed that synthetic peptides are able to lower not only the number of CD25-containing cells but the level of its express ion as well.