INHIBITION OF MITOGEN-STIMULATED PROLIFERATION OF HUMAN-LYMPHOCYTES IN-VITRO BY SYNTHETIC PEPTIDE-FRAGMENTS OF ALPHA-2 INTERFERON

Authors
DANILKOVICH AV FREZE KV TARGONI OS KARULIN AY SHEVALE AF GUSEV MV SUKHIKH GT
Citation
Av. Danilkovich et al., INHIBITION OF MITOGEN-STIMULATED PROLIFERATION OF HUMAN-LYMPHOCYTES IN-VITRO BY SYNTHETIC PEPTIDE-FRAGMENTS OF ALPHA-2 INTERFERON, Bulletin of experimental biology and medicine, 117(1), 1994, pp. 75-78
Citations number
8
Categorie Soggetti
Medicine, Research & Experimental
Journal title
Bulletin of experimental biology and medicine → ACNP
ISSN journal
00074888
Volume
117
Issue
1
Year of publication
1994
Pages
75 - 78
Database
ISI
SICI code
0007-4888(1994)117:1<75:IOMPOH>2.0.ZU;2-U
Abstract
Human alpha-2 interferon and peptides representing parts of the amino- acid sequence 124-138 of the IF molecule inhibit the proliferative res ponse of peripheral blood lymphocytes from healthy donors in vitro ind uced by ConA. It is shown that neither interferon alpha-2 nor biologic ally active peptides change the level of interleukin-2 ConA-induced pr oduction by human blood mononuclears.