CELLULAR MECHANISMS OF HYPERTROPHIC CARDIOMYOPATHY IN SPONTANEOUSLY HYPERTENSIVE RATS (SHR)

Authors
SEMENOV DE NEPOMNYASHCHIKH LM
Citation
De. Semenov et Lm. Nepomnyashchikh, CELLULAR MECHANISMS OF HYPERTROPHIC CARDIOMYOPATHY IN SPONTANEOUSLY HYPERTENSIVE RATS (SHR), Bulletin of experimental biology and medicine, 117(1), 1994, pp. 96-99
Citations number
13
Categorie Soggetti
Medicine, Research & Experimental
Journal title
Bulletin of experimental biology and medicine → ACNP
ISSN journal
00074888
Volume
117
Issue
1
Year of publication
1994
Pages
96 - 99
Database
ISI
SICI code
0007-4888(1994)117:1<96:CMOHCI>2.0.ZU;2-T
Abstract
It is shown that the weight dynamics of the body, heart and left ventr icular myocardium is similar in Wistar rats and SHR, but the number of cardiomyocytes in the 5th and 24th weeks of postnatal development is considerably higher in Wistar rats than in SHR. The earlier maturation of cardiomyocytes in SHR rats leads to their reduced proliferative ac tivity, thus blocking the growth of the cell population.