The most reasonable and socially acceptable development of cancer prev
ention should be the blending of the population approach, that is the
shifting of the distribution of risk factors across an entire populati
on in a favourable direction, with the high risk approach aimed at the
identification, surveillance and possibly early interventions on indi
viduals with particularly high values of predisposition to cancer. int
erventions aimed at reducing or eliminating genetically determined wea
knesses with regard to interactions with the environment, will not mak
e, therefore, in any way obsolete or redundant, interventions aimed at
eliminating or reducing exposure to environmental carcinogens.