Primary endobronchial localization of tuberculosis without change on c
hest X-ray is a rare clinical entity, and bronchoscopic examination is
most appropriate to reveal such an occurrence. A 38-year-old man and
a 52-year-old women underwent fibre-optic bronchoscopy many months aft
er the onset of cough with poor sputum and dyspnoea on exercise, chest
X-ray being normal. In both cases, a widespread granulomatous involve
ment of the tracheo-bronchial tree was found and cultures of bronchial
wash grew Mycobacterium tuberculosis. Patients recovered after 6 mont
hs of combined anti-tuberculous and steroid therapy; the granulomatous
lesions disappeared but stenoses were found in the trachea and/or mai
n bronchi. In one case, CO2 laser therapy was performed with no improv
ement.