O. Barlas et al., BROMOCRIPTINE-INDUCED CEREBROSPINAL-FLUID FISTULA IN PATIENTS WITH MACROPROLACTINOMAS - REPORT OF 3 CASES AND A REVIEW OF THE LITERATURE, Surgical neurology, 41(6), 1994, pp. 486-489
Bromocriptine therapy for macroprolactinoma induced cerebrospinal flui
d (CSF) rhinorrhea in three patients. The tumor had extended well beyo
nd the sella turcica and caused bony erosion in all the cases. All thr
ee patients responded to bromocriptine therapy rapidly. CSF fistula oc
curred concomitantly with the reduction of tumor size and caused menin
gitis in two of the patients. Withdrawal of bromocriptine resulted in
cessation of the leakage. One of the patients underwent transsphenoida
l repair. Two patients refused surgery. This potentially lethal compli
cation encountered in these three cases demonstrates the need for clos
e supervision of macroprolactinoma patients with skull base erosion pl
aced under bromocriptine therapy.