APPLICATION OF NEW COATINGS FOR VASCULAR GRAFTS BASED ON POLYACRYLIC SYSTEMS WITH ANTIAGGREGATING ACTIVITY

A study has been made of the behaviour of knitted and woven Dacron mes h used in the preparation of vascular grafts when coated with either a layer of poly(2-hydroxyethyl methacrylate) or co-polymers of 2-hydrox yethyl methacrylate with 5, 10 or 20 wt% of an acrylic derivative of s alicylic acid, 2-methacryloytoxybenzoic acid. In vitro studies were ca rried out to quantify the loss of polymer under flow conditions, and e x vivo studies were done in dogs to quantify the deposition of In-111- oxine-labelled platelets. The treated materials showed a lesser deposi tion of platelet thrombi when compared with the control group.