HUMAN PAPILLOMAVIRUS TYPE-16 ASSOCIATED WITH MULTIFOCAL TRANSITIONAL-CELL CARCINOMAS OF THE BLADDER IN 2 TRANSPLANTED PATIENTS

This report describes two cases of rapidly progressive, multifocal tra nsitional cell carcinomas of the bladder that developed in two patient s after renal and cardiac transplantation, respectively. In both cases human papillomavirus (HPV) type 16 DNA was detected using the polymer ase chain reaction DNA amplification method. To our knowledge, this HP V type has not been previously described in multifocal bladder transit ional cell carcinoma in transplanted patients. Our findings suggest th at HPV may play a major role in the development of rapidly progressive , multifocal transitional cell carcinoma in immunosuppressed patients.