LYMPHOGLANDULAR BODIES IN LYMPHOID LESIONS AND NONLYMPHOID ROUND-CELLTUMORS - A QUANTITATIVE ASSESSMENT

Lymphoglandular bodies (cytoplasmic fragments) were counted in 10 high power fields (HPF) of the smears in 35 cases of non-Hodgkin lymphoma (NHL), 26 Hodgkin's disease (HD), 36 reactive lymphadenitis, 24 non-ly mphoid round cell tumors, and 20 cases of secondaries in lymph nodes. The number of lymphoglandular bodies in both May-Grunwald-Giemsa (MGG) and hematoxylin-eosin (H&E) stained smears in NHL, HD, and reactive l ymphadenitis were significantly higher compared to non-lymphoid round cell tumors (P < 0. 001). In H&E stained smear 92.5% of NHL, 86.2% of reactive lymph nodes, and 66.7% of HD cases had > 100 lymphoglandular bodies per 10 HPF. In MGG stained smears 100% NHL, 89.7% of reactive l ymphadenitis, and 66.7% of HD cases contained > 100 lymphoglandular bo dies per 10 HPF. On the other hand only 4.8% of non-lymphoid round cel l tumors crossed this level in both H&E stained and MGG stained smears . Number of lymphoglandular bodies was also significantly higher in MG G stained smears compared to H&E stained smears (P < 0.05 to < a 01) a nd in fine-needle aspiration (FNA) smears compared to imprint smears ( P < 0.01 to < 0.001) in cases of NHL, HD, and reactive lymphadenitis. (C) 1994 Wiley-Liss, Inc.