A PAIRED-COMPARISON OF 2 MODELS OF EXPERIMENTAL RETINAL ISCHEMIA

Increased intraocular pressure and vascular ligation models are often used in studies of global ocular ischemia. The purpose of this study i s to perform a paired comparison of retinal recovery in these paradigm s. Our data indicate that ERG b-wave recovery profiles, following iden tical periods of ischemia, differ significantly between models. We pro pose that increased intraocular pressure models induce greater retinal injury than vascular ligation models. We suggest that pressure or ano ther aspect of the increased intraocular pressure model induces injury beyond that caused by ischemia alone and caution against direct compa rison of results obtained using these two models.