EARLY ELASTIC TRANSFORMATION OF A MYELOPROLIFERATIVE DISORDER WITH T(8-21) AND PROGRESSIVE ABERRATIONS OF CHROMOSOME-8

Authors
FASANARO A PAONE G SILVESTRI I MAROTTOLI V CIMINO R FERRARA F
Citation
A. Fasanaro et al., EARLY ELASTIC TRANSFORMATION OF A MYELOPROLIFERATIVE DISORDER WITH T(8-21) AND PROGRESSIVE ABERRATIONS OF CHROMOSOME-8, Cancer genetics and cytogenetics, 75(2), 1994, pp. 106-110
Citations number
15
Categorie Soggetti
Oncology,"Genetics & Heredity
Journal title
Cancer genetics and cytogenetics → ACNP
ISSN journal
01654608
Volume
75
Issue
2
Year of publication
1994
Pages
106 - 110
Database
ISI
SICI code
0165-4608(1994)75:2<106:EETOAM>2.0.ZU;2-V
Abstract
We describe a case of a patient affected by a chronic myeloproliferati ve disorder with t(8;21)(q22;q22) and trisomy 8 at diagnosis. At the t ime of blastic metamorphosis, 2 months later, trisomy 8 metaphases wer e significantly reduced, while a predominance of t(8;21) was present. Finally, in the phase of leukemic regrowth following chemotherapy admi nistration, monosomy 8 associated with der(21)t(8;21) was the predomin ant cytogenetic abnormality.